Graded and binary responses in stochastic gene expression.
نویسندگان
چکیده
Recently, several theoretical and experimental studies have been undertaken to probe the effect of stochasticity on gene expression (GE). In experiments, the GE response to an inducing signal in a cell, measured by the amount of mRNAs/proteins synthesized, is found to be either graded or binary. The latter type of response gives rise to a bimodal distribution in protein levels in an ensemble of cells. One possible origin of binary response is cellular bistability achieved through positive feedback or autoregulation. In this paper, we study a simple, stochastic model of GE and show that the origin of binary response lies exclusively in stochasticity. The transitions between the active and inactive states of the gene are random in nature. Graded and binary responses occur in the model depending on the relative stability of the activated and deactivated gene states with respect to that of mRNAs/proteins. The theoretical results on binary response provide a good description of the 'all-or-none' phenomenon observed in an eukaryotic system.
منابع مشابه
H∞ Sampled-Data Controller Design for Stochastic Genetic Regulatory Networks
Artificially regulating gene expression is an important step in developing new treatment for system-level disease such as cancer. In this paper, we propose a method to regulate gene expression based on sampled-data measurements of gene products concentrations. Inherent noisy behaviour of Gene regulatory networks are modeled with stochastic nonlinear differential equation. To synthesize feed...
متن کاملThe Effect of Aerobic Exercise and Melatonin on COX-2 Gene Expression in Spinal Cord Tissue and Neuropathic Pain Behavioral Responses in a Diabetic Rat Model
Introduction: Neuroinflammation plays an important role in developing many neurological changes in diabetic patients. This study aimed to investigate the effect of aerobic exercise and melatonin on COX-2 expression in spinal cord tissue and behavioral responses to pain caused by diabetic neuropathy in a rat model. Materials and Methods: Forty eight-week-old male Wistar rats (weight range 204 ± ...
متن کاملABCG5 gene responses to treadmill running with or without administration of Pistachio atlantica in female rats
Objective(s): ABC transporters comprise a large family of transmembrane proteins that use the energy provided by ATP hydrolysis to translocate a variety of substrates across biological membranes. All members of the human ABCG subfamily, except for ABCG2, are cholesterol-transporter. The aim of this study was to determine the liver, the small intestine and kidney ABCG5 relative gene expression...
متن کاملCloning and Expression of Recombinant Camelid Single-Domain Antibody in Tobacco
Antibodies provide a suitable tool in fundamental research and their high affinity and specificity make them invaluable for diagnostic and therapeutic applications. A promising alternative to conventional antibodies are the heavy chain antibodies (VHH) of Camelidae having short length, high solubility and stability are preferred to other antibody derivatives. In this study, our goal was product...
متن کاملStochastic switching in biology: from genotype to phenotype
There has been a resurgence of interest in non-equilibrium stochastic processes in recent years, driven in part by the observation that the number of molecules (genes, mRNA, proteins) involved in gene expression are often of order 1–1000. This means that deterministic mass-action kinetics tends to break down, and one needs to take into account the discrete, stochastic nature of biochemical reac...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Physical biology
دوره 1 3-4 شماره
صفحات -
تاریخ انتشار 2004